Tablet Disintegrant

"Polacrilin Potasium NF : AMBERLITE™ IRP88 

 

Many drugs are formulated as tablets for oral administration. The effectiveness of the drugs depends on the rate at which the tablet desintegrates in the gastrointestinal tract.  AMBERLITE™ IRP88 resin is an effective tablet disintegrant due to its extremely large swelling capacity in aqueous solutions. Water can exert force between particles within tablet pores, but this force is relatively low. In the presence of AMBERLITE™ IRP88 resin these forces are enhanced, resulting in rapid tablet disintegration.

 

Several factors that affect the formulation of drugs supplied as tablets are :

 

Water Absorption

AMBERLITE™ IRP88 resin will absorb water rapidly owing to its hydrophilic nature. 

 

Adhesion

The bonding of particles in compressed tablets must be overcome in order for a tablet to disintegrate, thereby releasing the drug. Some disintegrants, such as Sodium carboxymethyl cellulose and alginates, are adhesive in nature, and are thus ineffective in overcoming particle bonding. AMBERLITE™ IRP88 resin is nonadhesive and is more effective in such formulations.

 

Tablet Hardness 

This is an important factor to prevent the tablets from dusting or breaking up during packaging and shipping. Increasing the compressive force to reduce dusting can frequently retard the rate of subsequent disintegration. This result is obtained by adding for example 2% by weight AMBERLITE™ IRP88 resin.