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6-AminoPenicillinic acid (6-APA) : Penicillin G
Penicillins were the first antibiotic discovered by Sir Alexander Fleming in 1928 and are the largest volume antibiotic prescribed in the world today although the first major production occurred during the 1940's. Penicillins belong to the beta-lactum class of antibiotics and a number of different Penicillins have been identified. Of these Penicillin G and V were the most commercially important.
Current fermentation cultures give a relatively pure aqueous solution containing a high concentration of penicillin G. This has favoured the continued use of solvent extraction as the principal means of recovery.
However, ion exchange resins could be used to recover the Penicillin and with recent improvements both engineering and system design, there may be an opportunity to re-evaluate this possibility. In addition, there are several opportunities in the Penicillin recovery process where polymeric materials could be useful; two such areas are enzyme immobilisation (conversion of Penicillin G into 6-APA) and waste treatment (solvents etc.).
Products Guidelines:
Enzyme immobilisation : Amberlite™ FPC3500, Amberlite™ XAD™7HP