Modified Release
The rate at which a drug is released from a resinate is dependent on many factors but in its simplest form can be considered as an exponential curve. In many cases the rate is sufficiently slow that the resulting effect is an extended or sustained release over many hours albeit at an ever-changing concentration. By some practitioners, this exponential decline of release was considered as a limitation to the usefulness of ion exchange resins in extended release pharmaceutical formulations.
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However, novel recent work has demonstrated that the release rate of the drug from a formulation based on functional polymers can be accurately controlled with the potential for zero order release over prolonged periods.
This was demonstrated on a number of Diclofenac formulations |
This novel approach is the subject of a patent application and further details can be obtained by contacting Mr Marlin K. Kinzey.
Rohm and Haas has developed a novel GI dissolution system to demonstrate the performance of the improved formulations.
Products Guidelines:
Drugs with cationic functionality (e.g. -COOH or Na / K salts)
Drugs with anionic functionality (-NH2, HCl salts etc.)
