Dissolution Enhancement of Poorly Soluble Drugs
Many drugs, both in development and already available in the market, have the problem of being only poorly soluble in aqueous media. This can lead to poor bioavailability and frequently results in variable dissolution rates. Using Rohm and Haas Functional Polymers can greatly increase the rate at which these poorly soluble drugs dissolve. The Functional Polymers effectively avoid the lattice energy of the drug crystal, the main barrier to rapid dissolution in aqueous media, and does not require grinding the drug to ultrafine particles (such as the NanoCrystal® technology) or the addition of oils or surfactants. This technology is also applicable to drug substances which are heat sensitive and are present as oils. This technique is applicable to ionisable drugs, including cationic, anionic and amphoteric actives.
A well known example of this particular problem is Indomethacin.
Products Guidelines:
Drugs with cationic functionality (e.g. -COOH or Na / K salts)
Drugs with anionic functionality (-NH2, HCl salts etc.)
AMBERLITE™ IRP69, AMBERLITE™ IRP64, AMBERLITE™ IRP88
References : Improved Dissolution of Poorly Soluble Drugs
